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Principles of Bioseparations Engineering

282 Pages · 2007 · 6.98 MB · English

  • Principles of Bioseparations Engineering

    PRINCIPLES OF


    BIOSEPARATIONS


    ENGINEERING


    iffcS* RAIA GHOSH PRINCIPLES OF


    BIOSEPARATIONS


    ENGINEERING This page is intentionally left blank PRINCIPLES OF


    BIOSEPARATIONS


    ENGINEERING


    RAJA GHOSH


    McMaster University, Canada


    Y|* World Scientific


    NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI Published by


    World Scientific Publishing Co. Pte. Ltd.


    5 Toh Tuck Link, Singapore 596224


    USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601


    UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE


    British Library Cataloguing-in-Publication Data


    A catalogue record for this book is available from the British Library.


    Cover: Image courtesy of Millipore Corporation.


    PRINCIPLES OF BIOSEPARATIONS ENGINEERING


    Copyright © 2006 by World Scientific Publishing Co. Pte. Ltd.


    All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,


    electronic or mechanical, including photocopying, recording or any information storage and retrieval


    system now known or to be invented, without written permission from the Publisher.


    For photocopying of material in this volume, please pay a copying fee through the Copyright


    Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to


    photocopy is not required from the publisher.


    ISBN 981-256-892-1


    Printed in Singapore by World Scientific Printers (S) Pte Ltd To my wife, Sutapa This page is intentionally left blank Acknowledgements


    The author acknowledges with thanks the assistance provided by the individuals


    and organisations named below:


    Christine Zardecki of RCSB Protein Data Bank for kind permission to use images of


    protein and DNA structures (Figures 2.1, 2.2 and 2.3 of this book)


    Stanley Goldberg and Marc Lustig of Glen Mills Inc. and Andre Wrysch W. A.


    of Bachofen AG for providing me with Figures 4.5, 4.10 and 4.11 of this book


    and for their enthusiastic support for this project


    Dominic Spricigo of IKA® -WERKE GmbH & Co. KG for providing me with


    Figure 4.7 of this book


    Kevin McLaughlin of Shimadzu Scientific Instruments for providing me with


    Figure 9.4 of this book


    Gene Lauffer of Menardi for kind permission to use images of filtration devices


    from their website (Figures 10.7 and 10.10 of this book)


    Dana Hubbard, Susan Cheah and Shannon Meirzon of Millipore Corporation for


    providing me with Figures 11.4 (A, B and C), 11.12, 11.13 and 11.14 of this


    book


    PCI Membranes for providing me with Figure 11.15 of this book


    Shuichi Ogawa of Asahi Kasei for kind permission to use image of membrane


    filtration device from their website (Figure 11.16 of this book)


    Patricia Stancati of Sartorius for providing me with Figure 11.39 of this book


    Sandra Covelli and Michael Killeen of Pall Corporation for providing me with


    Figure 11.41 of this book


    vn This page is intentionally left blank Preface


    Bioseparations engineering refers to the systematic study of the


    scientific and engineering principles utilized for large-scale purification


    of biological products: biopharmaceuticals, biochemicals, foods,


    nutraceuticals and diagnostic reagents. Bioseparations engineering, both


    as an academic topic as well as an industrial practice has undergone


    significant growth and increase in importance in the past decade. Its


    entry into academia as a taught course took place as usually happens with


    any new topic: at the postgraduate level. It is now taught as a regular


    course in many undergraduate chemical and biomolecular engineering


    programs. It is also taught either as a separate course or indeed as a


    component of bioprocess engineering in almost all undergraduate and


    postgraduate programs in biotechnology.


    Most projects start with some necessity and this book is no exception.


    In the year 1999, as a new faculty member at Oxford University I was


    assigned to teach the relatively new C5A Bioprocess Engineering


    and C5B Separations courses for undergraduate engineering students.


    Both these courses were expected to have significant bioseparations


    engineering content and the main challenge I faced at that time was the


    lack of a satisfactory undergraduate level text book. I had learnt


    bioseparations engineering in the early 90s reading the seminal book on


    this topic by Belter, Cussler and Hu (Bioseparations: Downstream


    Processing for Biotechnology, John Wiley and Sons). However, this book


    had been published in 1988 and by end of the millennium was slightly


    dated. I therefore started developing my own course notes and handouts.


    These have formed the building blocks of this book and so in a sense,


    I effectively started writing this book in 1999. This is intended to be


    an undergraduate level text book, suitable for a one semester course on


    bioseparations engineering.


    IX


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