Principles of Bioseparations Engineering

282 Pages · 2007 · 6.98 MB · English

  • Principles of Bioseparations Engineering






    ENGINEERING This page is intentionally left blank PRINCIPLES OF




    McMaster University, Canada

    Y|* World Scientific


    World Scientific Publishing Co. Pte. Ltd.

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    British Library Cataloguing-in-Publication Data

    A catalogue record for this book is available from the British Library.

    Cover: Image courtesy of Millipore Corporation.


    Copyright © 2006 by World Scientific Publishing Co. Pte. Ltd.

    All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,

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    ISBN 981-256-892-1

    Printed in Singapore by World Scientific Printers (S) Pte Ltd To my wife, Sutapa This page is intentionally left blank Acknowledgements

    The author acknowledges with thanks the assistance provided by the individuals

    and organisations named below:

    Christine Zardecki of RCSB Protein Data Bank for kind permission to use images of

    protein and DNA structures (Figures 2.1, 2.2 and 2.3 of this book)

    Stanley Goldberg and Marc Lustig of Glen Mills Inc. and Andre Wrysch W. A.

    of Bachofen AG for providing me with Figures 4.5, 4.10 and 4.11 of this book

    and for their enthusiastic support for this project

    Dominic Spricigo of IKA® -WERKE GmbH & Co. KG for providing me with

    Figure 4.7 of this book

    Kevin McLaughlin of Shimadzu Scientific Instruments for providing me with

    Figure 9.4 of this book

    Gene Lauffer of Menardi for kind permission to use images of filtration devices

    from their website (Figures 10.7 and 10.10 of this book)

    Dana Hubbard, Susan Cheah and Shannon Meirzon of Millipore Corporation for

    providing me with Figures 11.4 (A, B and C), 11.12, 11.13 and 11.14 of this


    PCI Membranes for providing me with Figure 11.15 of this book

    Shuichi Ogawa of Asahi Kasei for kind permission to use image of membrane

    filtration device from their website (Figure 11.16 of this book)

    Patricia Stancati of Sartorius for providing me with Figure 11.39 of this book

    Sandra Covelli and Michael Killeen of Pall Corporation for providing me with

    Figure 11.41 of this book

    vn This page is intentionally left blank Preface

    Bioseparations engineering refers to the systematic study of the

    scientific and engineering principles utilized for large-scale purification

    of biological products: biopharmaceuticals, biochemicals, foods,

    nutraceuticals and diagnostic reagents. Bioseparations engineering, both

    as an academic topic as well as an industrial practice has undergone

    significant growth and increase in importance in the past decade. Its

    entry into academia as a taught course took place as usually happens with

    any new topic: at the postgraduate level. It is now taught as a regular

    course in many undergraduate chemical and biomolecular engineering

    programs. It is also taught either as a separate course or indeed as a

    component of bioprocess engineering in almost all undergraduate and

    postgraduate programs in biotechnology.

    Most projects start with some necessity and this book is no exception.

    In the year 1999, as a new faculty member at Oxford University I was

    assigned to teach the relatively new C5A Bioprocess Engineering

    and C5B Separations courses for undergraduate engineering students.

    Both these courses were expected to have significant bioseparations

    engineering content and the main challenge I faced at that time was the

    lack of a satisfactory undergraduate level text book. I had learnt

    bioseparations engineering in the early 90s reading the seminal book on

    this topic by Belter, Cussler and Hu (Bioseparations: Downstream

    Processing for Biotechnology, John Wiley and Sons). However, this book

    had been published in 1988 and by end of the millennium was slightly

    dated. I therefore started developing my own course notes and handouts.

    These have formed the building blocks of this book and so in a sense,

    I effectively started writing this book in 1999. This is intended to be

    an undergraduate level text book, suitable for a one semester course on

    bioseparations engineering.


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