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Pharmacology for Anaesthesia and Intensive Care

390 Pages · 2010 · 3.59 MB · English

  • Pharmacology for Anaesthesia and Intensive Care

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    PharmacologyforAnaesthesiaandIntensiveCare


    THIRD EDITION


    Thethirdeditionofthismarket-leadingbookhasbeenthoroughlyupdatedand


    expanded,withadditionalcontributionsfromexpertsinthefield,toincludeallnew


    drugsavailabletotheanaesthetistandintensivecarespecialist.Basic


    pharmacologicalprinciples,vitaltounderstandinghowindividualdrugsactually


    havetheireffects,aredealtwithmethodicallyandwithmanyhighlyannotated


    diagramsandtables.Withhospitalinfectionsbecomingincreasinglyprevalent,the


    importantsectiononantibioticshasbeenfurtherexpanded.Withthethirdedition,


    thiswellestablishedtitlecontinuestoprovideitsreaderswiththemostconciseyet


    comprehensivecoverageofallaspectsofpharmacology.Anidealaidtostudyand


    practiceforjuniorandtraineeanaesthetists,criticalcarenursesandallphysicians


    andhealthcareprofessionalsworkingintheatre,accidentandemergency


    departmentsorintensivecareunits.


    TomPeckisaConsultantAnaesthetistatRoyalHampshireCountyHospital,


    Winchester.


    SueHillisaConsultantNeuroanaesthetistatSouthamptonGeneralHospital.


    MarkWilliamsisaConsultantAnaesthetistatRoyalPerthHospital,Australia.


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    Pharmacology for Anaesthesia


    and Intensive Care


    THIRD EDITION


    TomPeck,SueHillandMarkWilliams


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    CAMBRIDGEUNIVERSITYPRESS


    Cambridge,NewYork,Melbourne,Madrid,CapeTown,Singapore,Sa˜oPaulo,Delhi


    CambridgeUniversityPress


    TheEdinburghBuilding,CambridgeCB28RU,UK


    PublishedintheUnitedStatesofAmericabyCambridgeUniversityPress,NewYork


    www.cambridge.org


    Informationonthistitle:www.cambridge.org/9780521704632


    (cid:1)C TomPeckSueHillandMarkWilliams2008


    Thispublicationisincopyright.Subjecttostatutoryexception


    andtotheprovisionsofrelevantcollectivelicensingagreements,


    noreproductionofanypartmaytakeplacewithout


    thewrittenpermissionofCambridgeUniversityPress.


    Firstpublished2000


    PrintedintheUnitedKingdomattheUniversityPress,Cambridge


    AcataloguerecordforthispublicationisavailablefromtheBritishLibrary.


    LibraryofCongressCataloging-in-PublicationData


    Peck,T.E.


    Pharmacologyforanaesthesiaandintensivecare/TomPeck,S.Hill,MarkWilliams.–3rded.


    p.;cm.


    Includesbibliographicalreferencesandindex.


    ISBN978-0-521-70463-2(pbk.)


    1.Pharmacology. 2.Anesthetics. 3.Anesthesia. 4.Criticalcaremedicine.


    I.Hill,S.A.(SueA.) II.Williams,Mark(MarkAndrew)1965- III.Title.


    [DNLM: 1.Anesthetics–pharmacology. 2.CardiovascularAgents–pharmacology.


    3.IntensiveCare.QV81P367p2007]


    RM300.P396 2007


    615(cid:2).1–dc22 2007029048


    ISBN978-0-521-70463-2paperback


    CambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracyofURLsfor


    externalorthird-partyinternetwebsitesreferredtointhispublication,anddoesnotguarantee


    thatanycontentonsuchwebsitesis,orwillremain,accurateorappropriate.


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    CONTENTS


    Preface page ix


    Foreword xi


    SECTION I Basicprinciples 1


    1 Drugpassageacrossthecellmembrane 1


    2 Absorption,distribution,metabolismandexcretion 8


    3 Drugaction 24


    4 Druginteraction 40


    5 Isomerism 45


    6 Mathematicsandpharmacokinetics 50


    7 Medicinalchemistry 85


    SECTION II Coredrugsinanaestheticpractice 99


    8 Generalanaestheticagents 99


    9 Analgesics 135


    10 Localanaesthetics 163


    11 Musclerelaxantsandanticholinesterases 175


    SECTION III Cardiovasculardrugs 197


    12 Sympathomimetics 197


    13 Adrenoceptorantagonists 217


    14 Anti-arrhythmics 228


    15 Vasodilators 246


    16 Antihypertensives 258


    SECTION IV Otherimportantdrugs 270


    17 Centralnervoussystem 270


    18 Antiemeticsandrelateddrugs 282


    19 Drugsactingonthegut 292


    20 Intravenousfluids 298


    21 Diuretics 305


    22 Antimicrobials 311


    23 Drugsaffectingcoagulation 335


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    vi Contents


    24 DrugsusedinDiabetes 347


    25 Corticosteroidsandother


    hormonepreparations 353


    Index 360 P1:PCX Printer:YetToCome


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    CONTRIBUTOR


    Dr.A.S.Grice,BSc,DCH,FRCA,ConsultantAnaesthetist,Exeter


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    PREFACE


    Thethirdeditionhasseenfurtherchanges.Themathematicssectionhasbeenover-


    hauledandexpandedtogiveabetterbaseforthekinetics.Anadditionalchapter


    hasbeenaddedonintravenousfluids,andthechaptersonintravenousandvolatile


    anaestheticshavebeencombinedwithanexpandedsectiononthemolecularmech-


    anismofanaesthesia.


    Wehavetriedtomaintainthestyleoftheprevioustwoeditionswithanemphasis


    onclaritybothintermsofpresentationandcontent.Inadditionwehavetriedvery


    hardtoeliminatethosesmallerrorsthataredisproportionatelyirritating.Wehope


    thatthisbookwillcontinuetobeahelpfulaidtothewiderangeofreadersitappears


    tohaveattracted.


    TomPeck


    SueHill


    MarkWilliams


    ix


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