Infectious Diseases in Critical Care Medicine

612 Pages · 2009 · 5.83 MB · English

  • Infectious Diseases in Critical Care Medicine


    Diseases in

    Critical Care


    Cunha_978-1420092400_TP.indd 1 10/5/09 4:21:18 PM INFECTIOUS DISEASE AND THERAPY

    Series Editor

    Burke A. Cunha

    Winthrop-University Hospital



    StateUniversity ofNewYorkSchoolof Medicine


    1. ParasiticInfectionsinthe CompromisedHost,editedby Peter D.WalterandRobert

    M. Genta

    2. Nucleic Acid and Monoclonal Antibody Probes: Applications in Diagnostic Method-

    ology, edited by Bala Swaminathan and Gyan Prakash

    3. Opportunistic Infections in Patients with the Acquired Immunodeficiency Syndrome,

    edited by Gifford Leoung and John Mills

    4. Acyclovir Therapy for Herpesvirus Infections, edited by David A. Baker

    5. The New Generation of Quinolones, edited by Clifford Siporin, Carl L. Heifetz, and

    John M. Domagala

    6. Methicillin-Resistant Staphylococcus aureus: Clinical Management and Laboratory

    Aspects, edited by Mary T. Cafferkey

    7. Hepatitis B Vaccines in Clinical Practice, edited by Ronald W. Ellis

    8. The New Macrolides, Azalides, and Streptogramins: Pharmacology and Clinical

    Applications, edited by Harold C. Neu, Lowell S. Young, and Stephen H. Zinner

    9. Antimicrobial Therapy in the Elderly Patient, edited by Thomas T. Yoshikawa and

    Dean C. Norman

    10. ViralInfectionsoftheGastrointestinalTract:SecondEdition,RevisedandExpanded,

    edited by Albert Z. Kapikian

    11. Development and Clinical Uses of Haemophilus b Conjugate Vaccines, edited by

    Ronald W. Ellis and Dan M. Cranoff

    12. PseudomonasaeruginosaInfectionsandTreatment,editedbyAldonaL.Battchand

    Raymond P. Smith

    13. Herpesvirus Infections, edited by Ronald Glaser and James F. Jones

    14. Chronic Fatigue Syndrome, edited by Stephen E. Straus

    15. Immunotherapy of Infections, edited by K. Noel Masihi

    16. Diagnosis and Management of Bone Infections, edited by Luis E. Jauregui

    17. DrugTransportinAntimicrobialandAnticancerChemotherapy,editedbyNafsikaH.


    18. NewMacrolides,Azalides,andStreptograminsinClinicalPractice,editedbyHarold

    C. Neu, Lowell S. Young, Stephen H. Zinner, and Jacques F. Acar

    19. Novel Therapeutic Strategies in the Treatment of Sepsis, edited by David C.

    Morrison and John L. Ryan

    20. Catheter-Related Infections, edited by Harald Seifert, Bernd Jansen, and Barry M.


    21. ExpandingIndicationsfortheNewMacrolides,Azalides,andStreptogramins,edited

    try Stephen H. Zinner, Lowell S. Young, Jacques F. Acar, and Harold C. Neu

    22. Infectious Diseases in Critical Care Medicine, edited by Burke A. Cunha 23. NewConsiderationsforMacrolides,Azalides,Streptogramins,andKetolides,edited

    by Stephen H. Zinner, Lowell S. Young, Jacques F. Acar, and Carmen Ortiz-Neu

    24. Tickborne Infectious Diseases: Diagnosis and Management, edited by Burke A.


    25. Protease Inhibitors in AIDS Therapy, edited by Richard C. Ogden and Charles W.


    26. Laboratory Diagnosis of Bacterial Infections, edited by Nevio Cimolai

    27. Chemokine Receptors and AIDS, edited by Thomas R. O’Brien

    28. Antimicrobial Pharmacodynamics in Theory and Clinical Practice, edited by Charles

    H. Nightingale, Takeo Murakawa, and Paul G. Ambrose

    29. Pediatric Anaerobic Infections: Diagnosis and Management, Third Edition, Revised

    and Expanded, Itzhak Brook

    30. ViralInfectionsandTreatment,editedbyHelgaRuebsamen-Waigmann,KarlDeres,

    Guy Hewlett, and Reinhotd Welker

    31. Community-Aquired Respiratory Infections, edited by Charles H. Nightingale, Paul

    G. Ambrose, and Thomas M. File

    32. Catheter-RelatedInfections:SecondEdition,editedbyHaraldSeifert,BerndJansen,

    and Barry Farr

    33. AntibioticOptimization:ConceptsandStrategiesinClinicalPractice(PBK),editedby

    Robert C. Owens, Jr., Charles H. Nightingale, and Paul G. Ambrose

    34. Fungal Infections in the Immunocompromised Patient, edited by John R. Wingard

    and Elias J. Anaissie

    35. Sinusitis: From Microbiology To Management, edited by Itzhak Brook

    36. Herpes Simplex Viruses, edited by Marie Studahl, Paola Cinque and Toms


    37. Antiviral Agents, Vaccines, and Immunotherapies, Stephen K. Tyring

    38. Epstein-Barr Virus, edited by Alex Tselis and Hal B. Jenson

    39. Infection Management for Geriatrics in Long-Term Care Facilities, Second Edition,

    edited by Thomas T. Yoshikawa and Joseph G. Ouslander

    40. Infectious Diseases in Critical Care Medicine, Second Edition, edited by Burke A.


    41. Infective Endocarditis: Management in the Era of Intravascular Devices, edited by

    John L. Brusch

    42. Fever of Unknown Origin, edited by Burke A. Cunha

    43. Rickettsial Diseases, edited by Didier Raoult and Philippe Parola

    44. Antimicrobial Pharmacodynamics in Theory and Clinical Practice, Second Edition,

    edited by Charles H. Nightingale, Paul G. Ambrose, George L. Drusano, and Takeo


    45. Clinical Handbook of Pediatric Infectious Disease, Third Edition, Russell W. Steele

    46. Anaerobic Infections: Diagnosis and Management, Itzhak Brook

    47. Diagnosis of Fungal Infections, edited by Johan A. Maertens and Kieren A. Marr

    48. AntimicrobialResistance:ProblemPathogensandClinicalCountermeasures,edited

    by Robert C. Owens, Jr. and Ebbing Lautenbach

    49. Lyme Borreliosis in Europe and North America, edited by, Sunil Sood

    50. Laboratory Diagnosis of Viral Infections, Fourth Edition, edited by Keith R. Jerome

    51. Infectious Diseases in Critical Care Medicine, Third Edition, edited by Burke A.

    Cunha Infectious

    Diseases in

    Critical Care


    Third Edition

    Edited by

    Burke A. Cunha

    Winthrop-University Hospital

    Mineola, New York, USA

    State University of New York School of Medicine

    Stony Brook, New York, USA

    Cunha_978-1420092400_TP.indd 2 10/5/09 4:21:18 PM InformaHealthcareUSA,Inc.







    10 9 8 7 6 5 4 3 2 1



    Thisbookcontainsinformationobtainedfrom authenticandhighlyregarded sources.Reprinted materialis quotedwith







    For permissiontophotocopyor usematerialelectronicallyfromthiswork,please accesswww.copyright.com(http://


    978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For


    Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for





    p.;cm.— (Infectiousdiseaseandtherapy;51)



    ISBN-10:1-4200-9240-5(hardcover:alk.paper) 1. Nosocomial

    infections.2. Criticalcaremedicine.3. Intensivecareunits.


    [DNLM:1. CommunicableDiseases—diagnosis.2. Communicable

    Diseases—therapy.3. CriticalCare.4. Diagnosis,Differential.5.

    IntensiveCareUnits. W1IN406HMNv.512009/WC100I41652009]









    www.informahealthcare.com for


    Peerless wife and mother,

    Provider of domestic peace and tranquility,

    Paragon of truth and beauty,

    Paradigm of earthly perfection . . .

    With gratitude for her love and constant support. Foreword

    In the United States during the 1950s, the development of mechanical ventilation led to the

    organization of special units in hospitals, where health care personnel with specific expertise

    could efficiently focus on patients with highly technical or complex needs. Over the ensuing

    years the sickest patients as well as those needing mechanical ventilation were grouped into

    special care units. In 1958, Baltimore City Hospital developed the first multidisciplinary

    intensive care unit. The concept of physician coverage 24 hours a day, seven days a week

    became a logical approach to providing optimal care to the sickest, most complex patients.

    Now,50years afterthefirstmultidisciplinary intensive careunitwasopened,there are

    now 5000 to 6000 intensive care units in the United States: Over 4000 hospitals offer one or

    more critical care units, and there are 87,000 intensive care unit beds. Critical care represents

    13.3% of hospital costs, totaling over $55 billion per year.


    unit. A substantial number of patients are admitted to the intensive care unit because of an


    to intensive care units for noninfectious disorders develop infections during their stay. Thus,

    intensivists need expertise in the diagnosis, treatment, and prevention of infectious diseases.

    Management of infections is pivotal to successful outcomes.

    In this third edition of Infectious Diseases in Critical Care Medicine, Burke Cunha has



    patients have life-threatening processes that evoke similar systemic inflammatory responses.


    strategy for initial patient management. Specific chapters focus on special intensive care unit

    problems, such as central venous catheter infections, nosocomial pneumonias, endocarditis,

    and Clostridium difficile infection. Particularly useful are chapters on special populations that

    many clinicians rarely encounter: tropical diseases, cirrhosis, burns, transplants, or tubercu-

    losis. Chapters on therapy also provide practical advice focused on critically ill patients, in


    different from patients who are less seriously ill.

    Critical care medicine is becoming more and more technology based. Genomics and

    proteomics can predict susceptibility to various diseases and drug metabolic problems.

    Patients can be assessedby ultrasonography to supplement physical examination. Diagnostic


    well as monitoring of central nervous system and cardiac activity is commonplace.

    Despite these advances in technology, knowledge of differential diagnosis, natural history,

    and therapeutic options is still essential. To understand these processes, Burke Cunha has

    assembled an impressive team of experienced clinicians to provide insight into the infectious



    Henry Masur

    Department of Critical Care Medicine

    Clinical Center

    National Institutes of Health

    Bethesda, Maryland, U.S.A.

    Please note: To fully download this free PDF,EBook files you need know All free.
    Found by internet command,site not saved pdf file
You May Also Like

Related PPT Template in the same category.